High-resolution characterization of the pancreatic adenocarcinoma genome.

  title={High-resolution characterization of the pancreatic adenocarcinoma genome.},
  author={Andrew James Aguirre and C. V. Weiss Brennan and Gerald Bailey and Raktim Sinha and Bin Feng and Christopher Leo and Yunyu Zhang and Jean Y Zhang and Joseph D. Gans and Nabeel Bardeesy and Craig Cauwels and Carlos Cordon-Cardo and Mark S. Redston and Ronald A. Depinho and Lynda Chin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={101 24},
The pancreatic adenocarcinoma genome harbors multiple amplifications and deletions, pointing to the existence of numerous oncogenes and tumor suppressor genes driving the genesis and progression of this lethal cancer. Here, array comparative genomic hybridization on a cDNA microarray platform and informatics tools have been used to define the copy number alterations in a panel of 24 pancreatic adenocarcinoma cell lines and 13 primary tumor specimens. This high-resolution genomic analysis has… CONTINUE READING
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