High-resolution atomic force microscopy of soluble Abeta42 oligomers.

@article{Mastrangelo2006HighresolutionAF,
  title={High-resolution atomic force microscopy of soluble Abeta42 oligomers.},
  author={I. Mastrangelo and Mahiuddin Ahmed and Takeshi Sato and W. Liu and Chengpu Wang and P. Hough and Steven O. Smith},
  journal={Journal of molecular biology},
  year={2006},
  volume={358 1},
  pages={
          106-19
        }
}
Soluble oligomers and protofibrils are widely thought to be the toxic forms of the Abeta42 peptide associated with Alzheimer's disease. We have investigated the structure and formation of these assemblies using a new approach in atomic force microscopy (AFM) that yields high-resolution images of hydrated proteins and allows the structure of the smallest molecular weight (MW) oligomers to be observed and characterized. AFM images of monomers, dimers and other low MW oligomers at early incubation… Expand
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