High-resolution analysis of paraffin-embedded and formalin-fixed prostate tumors using comparative genomic hybridization to genomic microarrays.

@article{Paris2003HighresolutionAO,
  title={High-resolution analysis of paraffin-embedded and formalin-fixed prostate tumors using comparative genomic hybridization to genomic microarrays.},
  author={Pamela L. Paris and Donna Albertson and Janneke C. Alers and Armann Andaya and Peter R. Carroll and Jane Fridlyand and Ajay N. Jain and Sherwin Kamkar and David Kowbel and P. -J. Krijtenburg and Dan Pinkel and Fritz H. Schroeder and Kees J. Vissers and Vivienne J E Watson and Mark F. Wildhagen and Colin Collins and Herman Van Dekken},
  journal={The American journal of pathology},
  year={2003},
  volume={162 3},
  pages={763-70}
}
We have used prostate cancer, the most commonly diagnosed noncutaneous neoplasm among men, to investigate the feasibility of performing genomic array analyses of archival tissue. Prostate-specific antigen and a biopsy Gleason grade have not proven to be accurate in predicting clinical outcome, yet they remain the only accepted biomarkers for prostate cancer. It is likely that distinct spectra of genomic alterations underlie these phenotypic differences, and that once identified, may be used to… CONTINUE READING