High-resolution analysis of chromosome rearrangements on 8p in breast, colon and pancreatic cancer reveals a complex pattern of loss, gain and translocation

@article{Pole2006HighresolutionAO,
  title={High-resolution analysis of chromosome rearrangements on 8p in breast, colon and pancreatic cancer reveals a complex pattern of loss, gain and translocation},
  author={Jessica C. M. Pole and C{\'e}line Courtay-Cahen and Mar{\'i}a Jos{\'e} Garc{\'i}a and Katherine A Blood and Susanna L. Cooke and Amber E. Alsop and David M. Tse and Carlos Caldas and Paul A. Edwards},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={5693-5706}
}
The short arm of chromosome 8, 8p, is often rearranged in carcinomas, typically showing distal loss by unbalanced translocation. We analysed 8p rearrangements in 48 breast, pancreatic and colon cancer cell lines by fluorescence in situ hybridization (FISH) and array comparative genomic hybridization, with a tiling path of 0.2 Mb resolution over 8p12 and 1 Mb resolution over chromosome 8. Selected breast lines (MDA-MB-134, MDA-MB-175, MDA-MB-361, T-47D and ZR-75-1) were analysed further. Most… CONTINUE READING
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