High-resolution X-ray structure of the DNA-binding protein HU from the hyper-thermophilic Thermotoga maritima and the determinants of its thermostability

@article{Christodoulou2002HighresolutionXS,
  title={High-resolution X-ray structure of the DNA-binding protein HU from the hyper-thermophilic Thermotoga maritima and the determinants of its thermostability},
  author={E. Christodoulou and W. Rypniewski and C. Vorgias},
  journal={Extremophiles},
  year={2002},
  volume={7},
  pages={111-122}
}
  • E. Christodoulou, W. Rypniewski, C. Vorgias
  • Published 2002
  • Biology, Medicine
  • Extremophiles
  • Abstract. The histone-like DNA-binding proteins (HU) are a convenient model for studying factors affecting thermostability because of their relatively simple, easily comparable structures, their common function, and their presence in organisms of widely differing thermostability. We report the determination of the high-resolution structure (1.53 Å) at 273 K and 100 K of the HU protein from the hyper-thermophilic eubacterium Thermotoga maritima (HUTmar, Tm=80.5 °C). The structural data presented… CONTINUE READING
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