High-resolution X-ray crystal structures of human gammaD crystallin (1.25 A) and the R58H mutant (1.15 A) associated with aculeiform cataract.

@article{Basak2003HighresolutionXC,
  title={High-resolution X-ray crystal structures of human gammaD crystallin (1.25 A) and the R58H mutant (1.15 A) associated with aculeiform cataract.},
  author={A. Basak and O. Bateman and C. Slingsby and A. Pande and N. Asherie and O. Ogun and G. Benedek and J. Pande},
  journal={Journal of molecular biology},
  year={2003},
  volume={328 5},
  pages={
          1137-47
        }
}
Several human cataracts have been linked to mutations in the gamma crystallin gene. One of these is the aculeiform cataract, which is caused by an R58H mutation in gammaD crystallin. We have shown previously that this cataract is caused by crystallization of the mutant protein, which is an order of magnitude less soluble than the wild-type. Here, we report the very high-resolution crystal structures of the mutant and wild-type proteins. Both proteins crystallize in the same space group and… Expand
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  • A. Pande, J. Pande, +4 authors G. Benedek
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2001
The γ-Crystallins and Human Cataracts: A Puzzle Made Clearer
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