High resolution IgH repertoire analysis reveals fetal liver as the likely origin of life-long, innate B lymphopoiesis in humans

@inproceedings{Roy2017HighRI,
  title={High resolution IgH repertoire analysis reveals fetal liver as the likely origin of life-long, innate B lymphopoiesis in humans},
  author={Anindita Roy and Vojtech Bystr{\'y} and Georg Bohn and Katerina Goudevenou and Tomas Reigl and Maria Papaioannou and Adam Krejci and Sorcha O'Byrne and Aristeidis I Chaidos and Andrea Grioni and Nikos Darzentas and Irene A.G. Roberts and Anastasios Karadimitris},
  booktitle={Clinical immunology},
  year={2017}
}
The ontogeny of the natural, public IgM repertoire remains incompletely explored. Here, high-resolution immunogenetic analysis of B cells from (unrelated) fetal, child, and adult samples, shows that although fetal liver (FL) and bone marrow (FBM) IgM repertoires are equally diversified, FL is the main source of IgM natural immunity during the 2nd trimester… CONTINUE READING