High-resolution ChIP-chip analysis reveals that the Drosophila MSL complex selectively identifies active genes on the male X chromosome.

@article{Alekseyenko2006HighresolutionCA,
  title={High-resolution ChIP-chip analysis reveals that the Drosophila MSL complex selectively identifies active genes on the male X chromosome.},
  author={Artyom A. Alekseyenko and Erica Larschan and Weil R. Lai and Peter J. Park and Mitzi I. Kuroda},
  journal={Genes & development},
  year={2006},
  volume={20 7},
  pages={
          848-57
        }
}
X-chromosome dosage compensation in Drosophila requires the male-specific lethal (MSL) complex, which up-regulates gene expression from the single male X chromosome. Here, we define X-chromosome-specific MSL binding at high resolution in two male cell lines and in late-stage embryos. We find that the MSL complex is highly enriched over most expressed genes, with binding biased toward the 3' end of transcription units. The binding patterns are largely similar in the distinct cell types, with… CONTINUE READING
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