High-resolution (1)H NMR and magic angle spinning NMR spectroscopic investigation of the biochemical effects of 2-bromoethanamine in intact renal and hepatic tissue.

@article{Garrod2001HighresolutionN,
  title={High-resolution (1)H NMR and magic angle spinning NMR spectroscopic investigation of the biochemical effects of 2-bromoethanamine in intact renal and hepatic tissue.},
  author={Sarah Garrod and E Humpher and Susan C. Connor and John C. Connelly and Manfred Spraul and Jeremy K. Nicholson and Elaine Holmes},
  journal={Magnetic resonance in medicine},
  year={2001},
  volume={45 5},
  pages={781-90}
}
The metabolic consequences of xenobiotic-induced toxicity were investigated using high-resolution magic angle spinning (MAS) NMR spectroscopy of intact tissue. Renal papillary necrosis (RPN) was induced in Sprague-Dawley rats (n = 12) via a single i.p. dose of 250 mg/kg 2-bromoethanamine (BEA) hydrobromide. At 2, 4, 6, and 24 h after treatment with BEA, three animals were killed and tissue samples were obtained from liver, renal cortex, and renal medulla. Tissue samples were also removed at 2… CONTINUE READING

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