High resolution "ultra performance" liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies.

@article{Wilson2005HighR,
  title={High resolution "ultra performance" liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies.},
  author={Ian D Wilson and Jeremy K. Nicholson and Jos{\'e} Manuel Castro-P{\'e}rez and Jennifer H Granger and Kelly A Johnson and Brian Wade Smith and Robert S Plumb},
  journal={Journal of proteome research},
  year={2005},
  volume={4 2},
  pages={
          591-8
        }
}
The combination of a new 1.7 mum reversed-phase packing material, and a chromatographic system, operating at ca. 12,000 psi, (so-called ultra performance liquid chromatography, UPLC) has enabled dramatic increases in chromatographic performance to be obtained for complex mixture separation. This increase in performance is manifested in improved peak resolution, together with increased speed and sensitivity. Here, we show that UPLC offers significant advantages over conventional reversed-phase… CONTINUE READING
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