High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis.

  title={High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis.},
  author={Andrew K. Godwin and Alton. Meister and Peter J O'dwyer and C. S. Huang and Thomas C. Hamilton and M. E. Anderson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={89 7},
  • A. Godwin, A. Meister, +3 authors M. Anderson
  • Published 1992
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
Exposure of human ovarian tumor cell lines to cisplatin led to development of cell lines that exhibited increasing degrees of drug resistance, which were closely correlated with increase of the levels of cellular glutathione. Cell lines were obtained that showed 30- to 1000-fold increases in resistance; these cells also had strikingly increased (13- to 50-fold) levels of glutathione as compared with the drug-sensitive cells of origin. These levels of resistance to cisplatin and the cellular… Expand
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