High remission rate in T-cell prolymphocytic leukemia with CAMPATH-1H.

  title={High remission rate in T-cell prolymphocytic leukemia with CAMPATH-1H.},
  author={C. Dearden and E. Matutes and B. Cazin and G. Tj{\o}nnfjord and A. Parreira and B. Nomdedeu and P. Leoni and F. J. Clark and D. Radia and S. M. Rassam and T. Roques and N. Ketterer and V. Brito-Babapulle and M. Dyer and D. Catovsky},
  volume={98 6},
  • C. Dearden, E. Matutes, +12 authors D. Catovsky
  • Published 2001
  • Medicine
  • Blood
  • T-cell prolymphocytic leukemia (T-PLL) is a chemotherapy-resistant malignancy with a median survival of 7.5 months. Preliminary results indicated a high remission induction rate with the human CD52 antibody, CAMPATH-1H. This study reports results in 39 patients with T-PLL treated with CAMPATH-1H between March 1993 and May 2000. All but 2 patients had received prior therapy with a variety of agents, including 30 with pentostatin; none achieved complete remission (CR). CAMPATH-1H (30 mg) was… CONTINUE READING
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