High recurrence of rearrangements involving chromosome 14 in an ataxia telangiectasia lymphoblastoid cell line and in its mutagen-treated derivatives

  title={High recurrence of rearrangements involving chromosome 14 in an ataxia telangiectasia lymphoblastoid cell line and in its mutagen-treated derivatives},
  author={D. Lefrançois and N. Kokalj and E. Vi{\'e}gas-P{\'e}quignot and L. Montagnier and B. Dutrillaux},
  journal={Human Genetics},
SummaryThe cytogenetic characterization of CH cell line obtained by Epstein-Barr-virus transformation of the lymphocytes of a patient affected by ataxia telangiectasia is reported. Control CH cells and 2 subcultures treated with the mutagens R7000 or NQO were developed in parallel and studied. A common chromosome anomaly, a der(14) t(11;14) (q13.2;q32), was found in all the studied karyotypes, indicating that it occurred either in vivo or early in vitro. In non-treated cultures, additional… Expand
3 Citations
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Tandem duplication q14 and dicentric formation by end-to-end chromosome fusions in ataxia telandiectasia (AT). Clinical and cytogenetic findings in 5 patients.
Chromosome studies on lymphocyte cultures were performed in 5 patients with AT, 2 of whom had been followed for 4 years. Four out of these patients showed an increased incidence of chromosome-typeExpand
Tandem duplication q14 and dicentric formation by end-to-end chromosome fusions in ataxia telangiectasia (AT)
Five patients with AT showed an increased incidence of chromosome-type aberrations, all of a peculiar type: in their formation no chromosome material was lost and they all seem to have arisen by end-to-end fusions. Expand
Probable involvement of immunoglobulin superfamily genes in most recurrent chromosomal rearrangements from ataxia telangiectasia
From the chromosomal analysis of 9461 lymphocytes from 57 patients affected by ataxia telangiectasia, it is concluded that bands 7p14, 7q35, 14q12, and 14qter are also too frequently involved in rearrangements with a few other chromosome sites. Expand
Molecular characterization of different ataxia telangiectasia T-cell clones
It is demonstrated that the T-cell receptor α-gene is split in at least two of these translocations, the first direct evidence of the involvement of a gene from the immunoglobulin superfamily in chromosomal rearrangements in ataxia telangiectasia. Expand
New data on clonal anomalies of chromosome 14 in ataxia telangiectasia: tct (14;14) and inv(14)
From a series of 53 patients with ataxia telangiectasia, two large clones with a t tan or tct(14;14) and two with an inv(14) were observed among phytohaemagglutinin (PHA)-stimulated lymphocytes, postulated that the rearrangements are related to a recombination of the α-chain of the T-cell receptor and IgH clusters of genes. Expand
High frequencies of inversions and translocations of chromosomes 7 and 14 in ataxia telangiectasia.
R-banding of lymphocytes and fibroblasts from 11 patients with ataxia telangiectasia showed rearrangements of chromosomes 7 and/or 14 in about 7% of the cells, and pericentric inversion of chromosome 7 was the most frequent, and the paracentric inversions of chromosome 14 not very rare. Expand
Clonal evolution of T‐cell chronic lymphocytic leukaemia in a patient with ataxia telangiectasia
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Report of the committee on structural chromosome changes in neoplasia.
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Growth of diploid, epstein‐barr virus‐carrying human lymphoblastoid cell lines heterotransplanted into nude mice under immunologically privileged conditions
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Epstein–Barr virus-induced cell fusion
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