High recombination rates and hotspots in a Plasmodium falciparum genetic cross

  title={High recombination rates and hotspots in a Plasmodium falciparum genetic cross},
  author={Hongying Jiang and Na Li and Vivek Gopalan and M. Zilversmit and S. Sunil Varma and Vijayaraj Nagarajan and Jian Hua Li and Jianbing Mu and Karen Hayton and Bruce Henschen and Ming Yi and Robert M. Stephens and Gilean McVean and Philip Awadalla and Thomas E Wellems and Xin-Zhuan Su},
  booktitle={Genome Biology},
The human malaria parasite Plasmodium falciparum survives pressures from the host immune system and antimalarial drugs by modifying its genome. Genetic recombination and nucleotide substitution are the two major mechanisms that the parasite employs to generate genome diversity. A better understanding of these mechanisms may provide important information for studying parasite evolution, immune evasion and drug resistance. Here, we used a high-density tiling array to estimate the genetic… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 37 extracted citations

Antimalarial Drug Resistance: A Threat to Malaria Elimination.

Cold Spring Harbor perspectives in medicine • 2017
View 2 Excerpts


Publications referenced by this paper.
Showing 1-10 of 50 references

Evidence on the chromosomal location of centromeric DNA in Plasmodium falciparum from etoposide-mediated topoisomerase-II cleavage.

Proceedings of the National Academy of Sciences of the United States of America • 2006
View 5 Excerpts
Highly Influenced

Chromosome sizedependent control of meiotic reciprocal recombination in Jiang

DB Kaback, D Barber, J Mahon, J Lamb, J You
Genome Biology • 2011

WHO: World Malaria Report 2008.[http://www.who.int/malaria/wmr2008/ malaria2008.pdf

View 1 Excerpt

Similar Papers

Loading similar papers…