High rates of ras codon 61 mutation in thyroid tumors in an iodide-deficient area.

@article{Shi1991HighRO,
  title={High rates of ras codon 61 mutation in thyroid tumors in an iodide-deficient area.},
  author={Y F Shi and M J Zou and H Schmidt and F Juhasz and V Stensky and D Robb and Nadir Rashad Farid},
  journal={Cancer research},
  year={1991},
  volume={51 10},
  pages={2690-3}
}
Using polymerase chain reaction and sequence-specific oligonucleotide hybridization, the frequency of three ras oncogene mutations (N-ras, Ha-ras, and K-ras) in thyroid tumors (25 adenomas, 16 follicular carcinomas, and 22 papillary carcinomas) was investigated in both iodide-deficient and iodide-sufficient areas. The ras oncogene mutation rate was significantly higher in the iodide-deficient area, being 85 versus 17% in the adenomas, and 50 versus 10% in the follicular carcinomas. No mutations… CONTINUE READING