High rates of fuel consumption are not required by insulating motifs to suppress retroactivity in biochemical circuits

@article{Deshpande2017HighRO,
  title={High rates of fuel consumption are not required by insulating motifs to suppress retroactivity in biochemical circuits},
  author={Abhishek Deshpande and Thomas E. Ouldridge},
  journal={arXiv: Molecular Networks},
  year={2017}
}
Retroactivity arises when the coupling of a molecular network $\mathcal{U}$ to a downstream network $\mathcal{D}$ results in signal propagation back from $\mathcal{D}$ to $\mathcal{U}$. The phenomenon represents a breakdown in modularity of biochemical circuits and hampers the rational design of complex functional networks. Considering simple models of signal-transduction architectures, we demonstrate the strong dependence of retroactivity on the properties of the upstream system, and explore… 

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