High rate of mutations in the hepatitis B core gene during the immune clearance phase of chronic hepatitis B virus infection.

@article{Bozkaya1996HighRO,
  title={High rate of mutations in the hepatitis B core gene during the immune clearance phase of chronic hepatitis B virus infection.},
  author={Hakan Bozkaya and B Ayola and A S Lok},
  journal={Hepatology},
  year={1996},
  volume={24 1},
  pages={32-7}
}
Cross-sectional studies reported that hepatitis B core gene mutations are associated with active liver disease and responsiveness to interferon therapy. In view of the heterogeneity in published sequences, it is not possible to tell whether the differences in sequences observed were true mutations that developed during the course of infection. We conducted a longitudinal study to determine the rate of hepatitis B core gene mutations and the timing of these mutations in relation to hepatitis B… CONTINUE READING
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