High rate of centrosome aberrations and correlation with proliferative activity in patients with untreated B-cell chronic lymphocytic leukemia.

@article{Hensel2007HighRO,
  title={High rate of centrosome aberrations and correlation with proliferative activity in patients with untreated B-cell chronic lymphocytic leukemia.},
  author={Manfred Hensel and Martin Zoz and Christian Giesecke and Axel Benner and Kai Neben and Anna Jauch and Stephan Stilgenbauer and Anthony D. Ho and Alwin Kraemer},
  journal={International journal of cancer},
  year={2007},
  volume={121 5},
  pages={978-83}
}
B-cell chronic lymphocytic leukemia (CLL) is characterized by a high rate of clonal genomic alterations and a low proliferative activity with cell cycle arrest in G(0)/G(1) phase. Recently, centrosome aberrations have been described as a possible cause of chromosomal instability and aneuploidy in many human malignancies. To investigate whether centrosome aberrations do occur in CLL and whether they correlate with common prognostic factors and disease activity, we examined peripheral blood… CONTINUE READING