High-quality draft assemblies of mammalian genomes from massively parallel sequence data.

Abstract

Massively parallel DNA sequencing technologies are revolutionizing genomics by making it possible to generate billions of relatively short (~100-base) sequence reads at very low cost. Whereas such data can be readily used for a wide range of biomedical applications, it has proven difficult to use them to generate high-quality de novo genome assemblies of… (More)
DOI: 10.1073/pnas.1017351108

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