High quality copy number and genotype data from FFPE samples using Molecular Inversion Probe (MIP) microarrays

@article{Wang2008HighQC,
  title={High quality copy number and genotype data from FFPE samples using Molecular Inversion Probe (MIP) microarrays},
  author={Yuker Wang and Victoria EH Carlton and George Karlin-Neumann and Ronald J. Sapolsky and Li Zhang and Martin Moorhead and Zhigang Wang and Andrea L. Richardson and Robert S. Warren and Axel Walther and Melissa L Bondy and Aysegul A. Sahin and Ralf Krahe and Musaffe Tuna and Patricia A. Thompson and Paul T. Spellman and Joe W. Gray and Gordon B. Mills and Malek Faham},
  journal={BMC Medical Genomics},
  year={2008},
  volume={2},
  pages={8 - 8}
}
A major challenge facing DNA copy number (CN) studies of tumors is that most banked samples with extensive clinical follow-up information are Formalin-Fixed Paraffin Embedded (FFPE). DNA from FFPE samples generally underperforms or suffers high failure rates compared to fresh frozen samples because of DNA degradation and cross-linking during FFPE fixation and processing. As FFPE protocols may vary widely between labs and samples may be stored for decades at room temperature, an ideal FFPE CN… CONTINUE READING

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