High-quality and high-throughput massively parallel sequencing of the human mitochondrial genome using the Illumina MiSeq.

@article{King2014HighqualityAH,
  title={High-quality and high-throughput massively parallel sequencing of the human mitochondrial genome using the Illumina MiSeq.},
  author={Jonathan L. King and Bobby L Larue and Nicole Novroski and Monika Stoljarova and Seung Bum Seo and Xiangpei Zeng and David H. Warshauer and Carey P. Davis and Walther Parson and Antti Sajantila and Bruce Budowle},
  journal={Forensic science international. Genetics},
  year={2014},
  volume={12},
  pages={
          128-35
        }
}
Mitochondrial DNA typing in forensic genetics has been performed traditionally using Sanger-type sequencing. Consequently sequencing of a relatively-large target such as the mitochondrial genome (mtGenome) is laborious and time consuming. Thus, sequencing typically focuses on the control region due to its high concentration of variation. Massively parallel sequencing (MPS) has become more accessible in recent years allowing for high-throughput processing of large target areas. In this study… CONTINUE READING
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