High-programmed death-1 levels on hepatitis C virus-specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infection.

@article{Rutebemberwa2008HighprogrammedDL,
  title={High-programmed death-1 levels on hepatitis C virus-specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infection.},
  author={Alleluiah Rutebemberwa and Stuart C. Ray and Jacquie Astemborski and Jordana S Levine and Lin Liu and Kimberly A. Dowd and Shalyn Catherine Clute and Changyu Wang and Alan J Korman and Alessandro Sette and John Sidney and Drew Mark Pardoll and Andrea L. Cox},
  journal={Journal of immunology},
  year={2008},
  volume={181 12},
  pages={8215-25}
}
Hepatitis C virus (HCV) is an important human pathogen that represents a model for chronic infection given that the majority of infected individuals fail to clear the infection despite generation of virus-specific T cell responses during the period of acute infection. Although viral sequence evolution at targeted MHC class I-restricted epitopes represents one mechanism for immune escape in HCV, many targeted epitopes remain intact under circumstances of viral persistence. To explore alternative… CONTINUE READING

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