High production of interferon gamma but not interleukin-2 by human T-lymphotropic virus type I-infected peripheral blood mononuclear cells.

@article{Hanon2001HighPO,
  title={High production of interferon gamma but not interleukin-2 by human T-lymphotropic virus type I-infected peripheral blood mononuclear cells.},
  author={Emmanuel Hanon and Peter K C Goon and Graham P Taylor and Hideki Hasegawa and Yuji Tanaka and Jonathan Weber and Charles R. M. Bangham},
  journal={Blood},
  year={2001},
  volume={98 3},
  pages={721-6}
}
The transactivator protein of human T-lymphotropic virus I (HTLV-I), Tax, has been associated with the up-regulation of several host cell genes, including interleukin 2 (IL-2), the IL-2 receptor-alpha (IL-2Ralpha) chain (CD25), interferon gamma (IFN-gamma), and tumor necrosis factor (TNF). It has been proposed that an IL-2/CD25 autocrine loop plays a part in maintaining the very high proviral loads often found in HTLV-I infection. Furthermore, abnormal production of inflammatory cytokines might… CONTINUE READING