High-producer allele of tumour necrosis factor-alpha is part of the susceptibility MHC haplotype in severe puumala virus-induced nephropathia epidemica.

@article{Kanerva1998HighproducerAO,
  title={High-producer allele of tumour necrosis factor-alpha is part of the susceptibility MHC haplotype in severe puumala virus-induced nephropathia epidemica.},
  author={Mervi Kanerva and Antti Vaheri and J. Peter Mustonen and Jukka Partanen},
  journal={Scandinavian journal of infectious diseases},
  year={1998},
  volume={30 5},
  pages={532-4}
}
The biallelic polymorphisms in the tumour necrosis factor-alpha (TNF-alpha) gene promoter region were studied in patients with nephropathia epidemica (NE). The rarer TNF2 allele, associated with a high TNF-alpha producer phenotype, was more frequently found in hospitalized NE patients (42%) than in healthy controls (15%; p=0.0064). The putative role of TNF2 as an independent risk factor for NE is discussed.