High prevalence of thyroid autoimmunity in idiopathic Addison's disease.

@article{KasperlikZauska1994HighPO,
  title={High prevalence of thyroid autoimmunity in idiopathic Addison's disease.},
  author={A. Kasperlik-Załuska and B. Czarnocka and W. Czech},
  journal={Autoimmunity},
  year={1994},
  volume={18 3},
  pages={
          213-6
        }
}
We have determined the incidence of autoimmune thyroid disorders in patients with Addison's disease. The material comprised 212 patients, 128 women and 84 men, aged 9-74 years. In 58 patients tuberculosis and in six patients other adrenal disorders were diagnosed. In the remaining 148 patients the auto-immune mechanism was the most probable cause of adrenocrotical insufficiency. In order to evaluate the thyroid abnormalities seen in patients with Addison's disease the T3, T4 (RIA), TSH (ELISA… Expand
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References

SHOWING 1-10 OF 18 REFERENCES
Association of Addison's disease with autoimmune disorders--a long-term observation of 180 patients.
TLDR
Autoimmune disorders were found in 80 patients; however, 125 patients were believed to have an autoimmune origin of adrenocortical insufficiency, and in 20 patients two or more autoimmune Disorders were found to coexist with Addison's disease. Expand
Two Types of Autoimmune Addison's Disease Associated with Different Polyglandular Autoimmune (PGA) Syndromes
TLDR
Evidence is provided to support the concept that the Addison's diseases in Type I and II PGA syndromes have different genetic bases, as related to HLA haplotypes, and possibly have different underlying pathogeneses. Expand
Comparison of serum thyroid microsomal and thyroid peroxidase autoantibodies in thyroid diseases.
TLDR
Results provide strong support for the concept that TPO accounts for virtually all of the antigenic determinants reacting with the autoantibodies commonly termed anti-M antibodies. Expand
21-hydroxylase, a major autoantigen in idiopathic Addison's disease
TLDR
Results indicate that 21-hydroxylase (P450c21), prominent in the zona glomerulosa of the adrenal cortex, is a major autoantigen in idiopathic Addison's disease. Expand
Identification by molecular cloning of an autoantigen associated with Addison's disease as steroid 17α-hydroxylase
TLDR
The results show that one of the key enzymes in steroid biosynthesis, 17 alpha-hydroxylase, is an autoantigen involved in the pathogenesis of adrenocortical failure. Expand
Polyglandular autoimmune syndrome: current concepts.
TLDR
The polyglandular autoimmune syndrome should be considered in patients with one or more of the disorders constituting the syndrome; this should facilitate early diagnosis and perhaps even prevention of other components of the disease. Expand
Interaction of highly purified thyroid peroxidase with anti-microsomal antibodies in autoimmune thyroid diseases
TLDR
The data suggest that anti-microsomal and anti-TPO immunoreactivity are presented by the same aAb, and the use of highly purified TPO and anti -TPO mAb would allow large scale studies of anti- TPO a Ab, necessary for investigating their pathological significance in thyroid disorders. Expand
Purification of the human thyroid peroxidase and its identification as the microsomal antigen involved in autoimmune thyroid diseases
TLDR
It has been demonstrated that sera with anti‐microsomal autoantibodies from patients presenting Graves' or Hashimoto's thyroiditis diseases were able to bind to purified TPO and to inhibit in a dose‐dependent manner the mAb binding to purifiedTPO, suggesting that TPO is the thyroid antigen termed to date the microsomal antigen. Expand
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