High prevalence of serum autoantibodies against the amino terminal of α-enolase in Hashimoto's encephalopathy

@article{Yoneda2007HighPO,
  title={High prevalence of serum autoantibodies against the amino terminal of $\alpha$-enolase in Hashimoto's encephalopathy},
  author={Makoto Yoneda and Akihiro Fujii and Akira Ito and Hiromi Yokoyama and Hiroto Nakagawa and Masaru Kuriyama},
  journal={Journal of Neuroimmunology},
  year={2007},
  volume={185},
  pages={195-200}
}
Recently, we discovered autoantibodies against the amino (NH(2))-terminal of alpha-enolase (NAE) in patients with Hashimoto's encephalopathy (HE) (83.3%; 5/6) [Fujii, A., Yoneda, M., Ito, T., Yamamura, O., Satomi, S., Higa, H., Kimura, M., Suzuki, M., Yamashita, M., Yuasa, T., Suzuki, H., Kuriyama, M., 2005. Autoantibodies against the amino terminal of alpha-enolase are a useful diagnostic marker of Hashimoto's encephalopathy. J. Neuroimmunol. 162, 130-136]. We further investigated the anti-NAE… Expand
[Hashimoto's encephalopathy].
  • M. Yoneda
  • Medicine
  • Nihon rinsho. Japanese journal of clinical medicine
  • 2015
TLDR
The clinicoimmunological features of 80 cases of HE with serum anti-NAE Abs from institutions throughout Japan found that the serum autoantibodies against the NH2-terminal of α-enolase (NAE) can serve as a highly specific diagnostic biomarker for HE. Expand
Gerstmann's Syndrome in a Patient Double-positive for Antibodies against the N-methyl-D-aspartate Receptor and NH2-terminal of α-enolase
TLDR
A 36-year-old Japanese woman presented with Gerstmann's syndrome followed by jerky involuntary movements, seizure, autonomic instability, and consciousness disturbance, suggesting that the diagnosis of Hashimoto encephalopathy requires the reasonable exclusion of alternative diagnoses, including anti-NMDAR encephalitis. Expand
Novel autoantigens recognized by CSF IgG from Hashimoto's encephalitis revealed by a proteomic approach
TLDR
The presence of these autoantibodies selectively in the CSF of HE patients may have important diagnostic and pathogenetic implications, since the autoimmune response to these enzymes may lead to vascular and/or neuronal damage, two major mechanisms involved in the pathogenesis of HE. Expand
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The unusual case of a 40-year-old patient who was referred to the Emergency room because of marked asthenia associated to nausea, vomiting, and ataxia has been diagnosed on the basis of the presence of thyroid autoantibodies and the responsiveness to corticosteroid treatment. Expand
Experimental evidence for alpha enolase as one potential autoantigen in the pathogenesis of both autoimmune thyroiditis and its related encephalopathy.
TLDR
The results suggest that ENO1Ab can cause thyrocyte damage via ADCC effect and impair cerebral function by disrupting the blood-brain barrier. Expand
Anti-glutamate receptor ɛ2 antibodies in psychiatric patients with anti-thyroid autoantibodies – A prevalence study in Japan
TLDR
The results suggest that anti-GluRɛ2 antibodies may be associated with the neuropsychiatric manifestation of PPATs, an anti-glutamate receptor antibody-related disease. Expand
Serial brain MRI changes related to autoimmune pathophysiology in Hashimoto encephalopathy with anti-NAE antibodies: A case-series study
TLDR
MRI lesions that fluctuate according to the disease condition were frequently observed in Hashimoto encephalopathy patients with anti-NAE antibodies, which suggests that these fluctuation may be associated with the autoimmune pathophysiology of HE. Expand
Anti-thyroperoxidase antibodies from patients with Hashimoto's encephalopathy bind to cerebellar astrocytes
TLDR
Specific astrocyte binding of anti-TPO aAb suggests a role of these aAb in the HE pathogenesis, and in immunofluorescence assays on monkey brain cerebellum sections, both HE patients' sera and anti- TPO monoclonal antibodies (mAb) were able to bind cerebellar cells expressing glial fibrillary acid protein. Expand
HASHIMOTO’S ENCEPHALOPATHY AND RARE CASES OF HYPERTHYROIDISM
  • 2009
Hashimoto’s encephalopathy (HE) is an association of autoimmune thyroiditis with encephalopathy covering a great variety of neuropsychiatric symptoms. This term, though somewhat controversial, isExpand
[Diagnosis and treatments of Hashimoto's encephalopathy].
  • M. Yoneda
  • Medicine
  • Rinsho shinkeigaku = Clinical neurology
  • 2012
TLDR
The clinical features and treatments in 80 cases of Hashimoto's encephalopathy with serum anti-NH(2)-terminal of α-enolase [anti-NAE] autoantibodies, a useful diagnostic marker of this disease, are investigated, and patients should be aware of the possibility of HE for early diagnosis and treatment. Expand
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Neither the carboxyl terminal nor the mid-region of alpha-enolase showed specificity for Hashimoto's encephalopathy, but autoantibodies against the amino terminal ofalpha- enolase are a useful diagnostic marker forHashimoto'sEncephalopathy. Expand
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