High prevalence of plasma lipid abnormalities in human and canine Duchenne and Becker muscular dystrophies depicts a new type of primary genetic dyslipidemia.

@article{White2020HighPO,
  title={High prevalence of plasma lipid abnormalities in human and canine Duchenne and Becker muscular dystrophies depicts a new type of primary genetic dyslipidemia.},
  author={Zoe White and Chady H Hakim and Marine Theret and N Nora Yang and Fabio M. V. Rossi and D Cox and Gordon A. Francis and Volker Straub and Kathryn Selby and Constadina Panagiotopoulos and Dongsheng Duan and Pascal Bernatchez},
  journal={Journal of clinical lipidology},
  year={2020}
}
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References

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Increased plasma lipid levels exacerbate muscle pathology in the mdx mouse model of Duchenne muscular dystrophy
TLDR
It is suggested that plasma lipids could be primary contributors to human DMD severity and that the notoriously mild phenotype of mdx mice might be attributable in part to their endogenously low plasma lipid profiles, and DMD patients may benefit from lipid-lowering and vascular-targeted therapies.
Age‐dependent changes in metabolite profile and lipid saturation in dystrophic mice
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Associations between MRI‐T2, a strong indicator of inflammation/edema, with tissue and serum lipid profiles indicate the complex temporal changes of metabolite and lipid profiles during repetitive bouts of muscle damage and regeneration that occur in dystrophic muscle.
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Current knowledge supports the likelihood that interactions between the primary genetic defect and disruptions in the normal production of free radicals contribute to the pathophysiology of muscular dystrophies.
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It is shown that simvastatin dramatically improves muscle strength and fatigue resistance in DMD (mdx) mice and substantially improves the overall health and function of dystrophic skeletal muscles and may provide an unexpected, novel therapy for DMD and related neuromuscular diseases.
An intronic LINE-1 element insertion in the dystrophin gene aborts dystrophin expression and results in Duchenne-like muscular dystrophy in the corgi breed
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High resolution NMR based analysis of serum lipids in Duchenne muscular dystrophy patients and its possible diagnostic significance
TLDR
Proton NMR spectroscopic investigations on the lipid extract of the serum of Duchenne muscular dystrophy patients and healthy subjects in the northern Indian population may provide the possibility of the diagnostic importance for DMD, especially in cases where genetic analysis fails to provide the diagnosis.
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TLDR
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Microdystrophin Gene Therapy of Cardiomyopathy Restores Dystrophin-Glycoprotein Complex and Improves Sarcolemma Integrity in the Mdx Mouse Heart
TLDR
The results revealed the promise of AAV-microdystrophin gene therapy for cardiomyopathy in DMD and established a simple gene transfer method for efficient and persistent transduction of the mdx mouse heart.
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