High prevalence of p53 exon 4 mutations in soft tissue sarcoma.

  title={High prevalence of p53 exon 4 mutations in soft tissue sarcoma.},
  author={Parimal Das and Dhanasekaran Kotilingam and Borys Korchin and Jeuhui Liu and Dihua Yu and Alexander J F Lazar and Raphael E Pollock and Dina Chelouche Lev},
  volume={109 11},
BACKGROUND p53 is the most commonly mutated gene in cancer, including soft tissue sarcoma (STS). The authors characterized p53 alterations (protein accumulation and gene mutation) in STS to evaluate possible associations with patient outcomes. METHODS Thirty-one STS specimens (multiple histologies) were analyzed by p53 immunohistochemistry (IHC) and direct DNA sequencing of p53 exons 2-11 and then correlated with outcomes. RESULTS Direct p53 sequencing detected mutations in 10 of 31 STSs; 7… CONTINUE READING


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