High prevalence of long QT syndrome-associated SCN5A variants in patients with early-onset lone atrial fibrillation.

@article{Olesen2012HighPO,
  title={High prevalence of long QT syndrome-associated SCN5A variants in patients with early-onset lone atrial fibrillation.},
  author={Morten Salling Olesen and Lei Yuan and Bo Liang and Anders Gaarsdal Holst and Nikolaj B\orty Nielsen and Jonas Bille Nielsen and Paula Louise Hedley and Michael Christiansen and S. -P. Olesen and Stig Hauns\o and Nicole Schmitt and Thomas Jespersen and Jesper Hastrup Svendsen},
  journal={Circulation. Cardiovascular genetics},
  year={2012},
  volume={5 4},
  pages={
          450-9
        }
}
BACKGROUND Atrial fibrillation (AF) is the most common cardiac arrhythmia. The cardiac sodium channel, Na(V)1.5, plays a pivotal role in setting the conduction velocity and the initial depolarization of the cardiac myocytes. We hypothesized that early-onset lone AF was associated with genetic variation in SCN5A. METHODS AND RESULTS The coding sequence of SCN5A was sequenced in 192 patients with early-onset lone AF. Eight nonsynonymous mutations (T220I, R340Q, T1304M, F1596I, R1626H, D1819N… CONTINUE READING
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