Insights into the management of Wilson's disease.
- Mohmadshakil Kathawala, Gideon M Hirschfield
- Therapeutic advances in gastroenterology
- 2017
High prevalence of fulminant hepatic failure among patients with mutant alleles for truncation of ATP7B in Wilson's disease.
@article{Okada2010HighPO,
title={High prevalence of fulminant hepatic failure among patients with mutant alleles for truncation of ATP7B in Wilson's disease.},
author={Toshihide Okada and Yuta Shiono and Yoshibumi Kaneko and Kazuhiro Miwa and Kenkei Hasatani and Yoshiaki Hayashi and Hiroshi Mibayashi and Hiroyuki Aoyagi and Shigetsugu Tsuji and Masashi Yoshimitsu and Hisao Hayashi and Masakazu Yamagishi},
journal={Scandinavian journal of gastroenterology},
year={2010},
volume={45 10},
pages={1232-7}
}- Published 2010 in Scandinavian journal of gastroenterology
DOI:10.3109/00365521.2010.492527
OBJECTIVE
Although many mutations of the Wilson's disease (WD) gene (ATP7B) have been reported, few data exist regarding the occurrence of fulminant hepatic failure (FHF). We sought to determine if genotypic assignment according to type of protein-product could be related to the prevalence of FHF among patients with WD.
MATERIAL AND METHODS
We performed gene analysis in Japanese patients with WD as well as genotype-phenotype analysis in 51 patients. We divided genotypes into two groups… CONTINUE READING