High prevalence of drug resistance amongst HIV-exposed and -infected children in a tuberculosis prevention trial [Short communication].

  title={High prevalence of drug resistance amongst HIV-exposed and -infected children in a tuberculosis prevention trial [Short communication].},
  author={Anneke Catharina Hesseling and Soyeon Kim and Shabir A Madhi and Sharon A. Nachman and Hendrik Simon Schaaf and Avy Violari and Thomas Calldo Victor and George D. McSherry and Charles D. Mitchell and M F Cotton},
  journal={The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease},
  volume={16 2},
An emergence of drug-resistant tuberculosis (DR-TB) in settings affected by human immunodeficiency virus (HIV) and tuberculosis (TB) has been observed. We investigated the prevalence of DR-TB in P1041, a multicentred, randomised, double-blind trial which compared the administration of isoniazid (INH) to placebo, in HIV-exposed, non-infected and -infected African infants in the absence of any documented TB exposure. The prevalence of multidrug-resistant TB (MDR-TB) was 22.2% (95%CI 8.5-45.8) and… CONTINUE READING
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