High prevalence of complement component C6 deficiency among African-Americans in the south-eastern USA.

@article{Zhu2000HighPO,
  title={High prevalence of complement component C6 deficiency among African-Americans in the south-eastern USA.},
  author={Z B Zhu and T Prescott Atkinson and K T Hovanky and Suresh B. Boppana and Yunping Dai and Peter Densen and Rodney C-P Go and Jerzy Jablecki and John E. Volanakis},
  journal={Clinical and experimental immunology},
  year={2000},
  volume={119 2},
  pages={305-10}
}
Complement component C6 is a part of the membrane attack complex that forms a pore-like structure in cell membranes following complement activation. Deficiency of terminal complement components including C6 predisposes individuals to infection with Neisseriae. Using polymerase chain reaction/single-strand conformation polymorphism analysis followed by DNA sequencing, we screened genomic DNA from 200 randomly chosen blacks and an equal number from whites for three loss-of-function C6 mutations… CONTINUE READING
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