High prevalence of autoantibodies against carbonic anhydrase II and lactoferrin in type 1 diabetes: concept of autoimmune exocrinopathy and endocrinopathy of the pancreas.

@article{Taniguchi2003HighPO,
  title={High prevalence of autoantibodies against carbonic anhydrase II and lactoferrin in type 1 diabetes: concept of autoimmune exocrinopathy and endocrinopathy of the pancreas.},
  author={Takao Taniguchi and Kazuichi Okazaki and Motozumi Okamoto and Shuji Seko and Juntaro Tanaka and Kazushige Uchida and Kazuaki Nagashima and Takeshi Kurose and Yuichiro Yamada and Tsutomu Chiba and Yutaka Seino},
  journal={Pancreas},
  year={2003},
  volume={27 1},
  pages={
          26-30
        }
}
INTRODUCTION Dysfunction of the exocrine as well as the endocrine pancreas has been reported in type 1 diabetes. Lymphocytic infiltration of the exocrine pancreas is observed in approximately half of Japanese type 1 diabetic patients. AIMS To investigate the involvement of autoimmunity against the exocrine pancreas in type 1 diabetes. METHODOLOGY We examined autoantibodies against human carbonic anhydrase II (ACA) and lactoferrin (ALF), antigens in the pancreatic duct cells and the… CONTINUE READING
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