High prevalence of antiphosphatidylinositol antibodies in young patients with cerebral ischemia of undetermined cause.

@article{Toschi1998HighPO,
  title={High prevalence of antiphosphatidylinositol antibodies in young patients with cerebral ischemia of undetermined cause.},
  author={Vincenzo Toschi and Angela Motta and Cristina Castelli and M L Paracchini and Dominic G Zerbi and A. Gibelli},
  journal={Stroke},
  year={1998},
  volume={29 9},
  pages={1759-64}
}
BACKGROUND AND PURPOSE Anticardiolipin antibodies (aCL) are associated with thrombotic phenomena including cerebral ischemia in young adults. Although aCL are directed to a neoepitope formed by phospholipid and beta2-glycoprotein I (beta2-GPI), immunoassays based on cardiolipin as target antigen are widely used. We previously demonstrated that 47% of aCL-negative systemic lupus erythematosus (SLE) patients had antiphospholipid antibodies (aPL) to epitopes other than cardiolipin, and we found an… CONTINUE READING