High prevalence of antibodies to lymphocytic choriomeningitis virus in a murine typhus endemic region in Croatia

  title={High prevalence of antibodies to lymphocytic choriomeningitis virus in a murine typhus endemic region in Croatia},
  author={Marinko Dobec and Boris D{\vz}elalija and Volga Punda-Poli{\'c} and Ivan Zori{\'c}},
  journal={Journal of Medical Virology},
A retrospective serological survey was carried out by the indirect immunofluorescence assay (IFA) and complement fixation (CF) test in a sample of 425 healthy residents (240 females and 185 males) to investigate whether Lymphocytic choriomeningitis virus (LCMV) circulates in the rural area of the northern Croatian island of Vir, which is known to be endemic for murine typhus. The overall prevalence of LCMV antibodies detected by IFA was found to be 36% (155 out of 425) and 13% (54 out of 425… 
Prevalence and Risk Factors for Lymphocytic Choriomeningitis Virus Infection in Continental Croatian Regions
Results of logistic regression showed that the presence of rodents in the house/yard and cleaning rodent nests were associated with an elevated risk for LCMV infection and the seroprevalence ofLCMV in continental Croatian regions was analyzed.
Identification of potential novel hosts and the risk of infection of lymphocytic choriomeningitis virus in humans in Gabon, Central Africa.
  • Y. Ushijima, Haruka Abe, J. Yasuda
  • Biology
    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
  • 2021
Development and application of ELISA for the detection of IgG antibodies to lymphocytic choriomeningitis virus.
The developed ELISA assay provides a fast, simple and efficient tool for the clinical detection of anti-nucleoprotein antibodies in human sera and demonstrates that ELISA is more sensitive than the indirect immunofluorescence antibody test (IFA).
Lymphocytic Choriomeningitis—Emerging Trends of a Neglected Virus: A Narrative Review
Clinicians should be aware of the risks posed by LCMV and should consider the virus in the differential diagnosis of aseptic meningitis, especially in patients who reported contact with rodents and in infants and children with unexplained hydrocephalus, intracerebral calcifications and chorioretinitis.
Emerging and Neglected Viruses of Zoonotic Importance in Croatia
Several arboviruses have emerged in Croatia in recent years and represent a significant healthcare burden since rotavirus vaccination is not included in the Croatian national immunization program.
Emerging Rodent-Borne Viral Zoonoses in Trento, Italy
The general exposure of residents in the Alps to these viruses has probably increased during the last decade, providing an early warning to public health authorities, and more detailed diagnostic and clinical investigations on suspected cases are suggested.
Lymphocytic Choriomeningitis Virus Infections and Seroprevalence, Southern Iraq
Acute febrile neurological infection cases in southern Iraq (N = 212) were screened for lymphocytic choriomeningitis virus (LCMV). Two LCMV IgM–positive serum samples and 2 cerebrospinal fluid
Peptide motif analysis predicts lymphocytic choriomeningitis virus as trigger for multiple sclerosis.
Selection of Diagnostic Cutoffs for Murine Typhus IgM and IgG Immunofluorescence Assay: A Systematic Review
There is a lack of consensus in the establishment of a single-value cutoff for murine typhus, and further studies will need to be executed at each distinct geographic location to identify region-specific cutoffs, while also considering background antibody levels to distinguish between healthy and infected patients.
Limfocytarne zapalenie splotu naczyniówkowego i opon mózgowych, LCM (Lymphocytic choriomeningitis)
Basic information is presented about the recognition and threats caused by infection with the LCM virus, which occurs worldwide and can lead to inflammation of the choroid plexus and meninges, giving a flu‐like syndrome.


Serological study of the lymphochoriomeningitis virus (LCMV) in an inner city of Argentina
This study is the first evidence on endemic LCMV in an Argentine city located outside the endemic area of Argentine hemorrhagic fever (AHF) and described the need to study other areas and increase awareness of this viral infection.
Lymphocytic choriomeningitis virus infection in a province of Spain: Analysis of sera from the general population and wild rodents
Results confirm the occurrence of LCMV infections in Man and rodents in Spain and no statistical differences in prevalence were found withrespect to either age or rural or urban residence, but differences were seen with respect to sex.
Age distribution of lymphocytic choriomeningitis virus serum antibody in Birmingham, Alabama: evidence of a decreased risk of infection.
Sera from an age-stratified sample of hospital patients in Birmingham, Alabama were tested for LCMV antibody by ELISA and data are consistent with a decreased incidence of humanLCMV infection in Birmingham over the past 30-40 years.
Serologic diagnosis of human infections with lymphocytic choriomeningitis virus: Comparative evaluation of seven methods
The aim of this work was to compare different procedures for the serodiagnosis of human infections with the lymphocytic choriomeningitis (LCM) virus and to single out those which are both reliable
Laboratory studies of a lymphocytic choriomeningitis virus outbreak in man and laboratory animals.
Investigation of an outbreak of prolonged febrile illness in medical center personnel at the University of Rochester School of Medicine and Dentistry revealed lymphocytic choriomeningitis (LCM) virus
Lymphocytic choriomeningitis virus: an unrecognized teratogenic pathogen.
It is suggested that LCMV is a more frequent cause of CNS disease in newborns than previously recognized and the similarities between these and features observed earlier in Europe are outlined.
Seroprevalence of lymphocytic choriomeningitis virus in Nova Scotia.
  • T. Marrie, M. Saron
  • Medicine
    The American journal of tropical medicine and hygiene
  • 1998
It is concluded that infection with LCMV is present in Nova Scotia and females are more likely to be infected than males.
  • E. Traub
  • Biology, Medicine
    The Journal of experimental medicine
  • 1938
Mice infected in utero continued to carry choriomeningitis virus in the blood more regularly and in greater amount than suckling mice infected by contact, and carrier mice without exception had a high degree of immunity to intracerebral injection with virus, while other animals once infected but no longer carrying detectable amounts of virus inThe blood often showed an incomplete immunity that manifested itself in an accelerated, non-fatal reaction.
Lymphocytic choriomeningitis virus infection and house mouse (Mus musculus) distribution in urban Baltimore.
The focal nature of LCMV infection in house mice may result from contact or vertical transmission of virus in conjunction with the highly structured social system of mice, which promotes inbreeding and limited dispersal.
Antigenic properties of the arenaviruses.
Investigations are reported showing that, as regards the CF test, Junin, Machupo, Amapari, and Tacaribe viruses are closely related, while LCM and Lassa viruses are distantly related to each other and to the remaining viruses in the group.