High prevalence of alpha-thalassemia among individuals with microcytosis and hypochromia without anemia.

@article{Borges2001HighPO,
  title={High prevalence of alpha-thalassemia among individuals with microcytosis and hypochromia without anemia.},
  author={Elizabeth Lage Borges and Marcia R S C Wenning and Elza Miyuki Kimura and Sirlei Gerv{\'a}sio and Fernando F. Costa and Maria de F{\'a}tima Sonati},
  journal={Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas},
  year={2001},
  volume={34 6},
  pages={759-62}
}
In order to determine the contribution of alpha-thalassemia to microcytosis and hypochromia, 339 adult outpatients seen at Unicamp University Hospital (with the exception of the Clinical Hematology outpatient clinics), who showed normal hemoglobin (Hb) levels and reduced mean corpuscular volume and mean corpuscular hemoglobin, were analyzed. Ninety-eight were Blacks (28.9%) and 241 were Caucasians (71.1%). In all cases, Hb A2 and F levels were either normal or low. The most common deletional… CONTINUE READING

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A base substitution (T®C) in codon 29 of the a2-globin gene causes a thalassemia

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a - Thalassaemia

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