High prevalence of activated intraepithelial cytotoxic T lymphocytes and increased neoplastic cell apoptosis in colorectal carcinomas with microsatellite instability.

@article{Dolcetti1999HighPO,
  title={High prevalence of activated intraepithelial cytotoxic T lymphocytes and increased neoplastic cell apoptosis in colorectal carcinomas with microsatellite instability.},
  author={Riccardo Dolcetti and Alessandra Viel and Claudio Doglioni and Angelo Russo and Massimo Guidoboni and Eugenia Capozzi and N Vecchiato and Ettore Macr{\'i} and Mara Fornasarig and Mauro Boiocchi},
  journal={The American journal of pathology},
  year={1999},
  volume={154 6},
  pages={1805-13}
}
Microsatellite instability (MSI) characterizes colorectal carcinomas (CRCs) in hereditary nonpolyposis colorectal cancer (HNPCC) syndrome and a proportion of sporadic CRCs. These MSI+ CRCs share several clinicopathological features, including a reputation for better survival rates than MSI- cases and a pronounced stromal inflammatory reaction of still undefined nature. In the present study, the presence, spatial distribution, and activation status of infiltrating cytotoxic effectors were… CONTINUE READING
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