High prevalence of GPRC5A germline mutations in BRCA1-mutant breast cancer patients.


In a search for new breast cancer (BC) predisposing genes, we performed a whole exome sequencing analysis using six patient samples of familial BC and identified a germline inactivating mutation c.183delG [p. Arg61fs] in an orphan G protein-coupled receptor GPRC5A. An extended case-control study revealed a tenfold enrichment for this mutation in BC patients… (More)
DOI: 10.1002/ijc.28569


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