High prevalence of BRCA1 and BRCA2 mutations in unselected Nigerian breast cancer patients.

@article{Fackenthal2012HighPO,
  title={High prevalence of BRCA1 and BRCA2 mutations in unselected Nigerian breast cancer patients.},
  author={James Fackenthal and Jing Zhang and Bifeng Zhang and Yonglan Zheng and Fitsum G. Hagos and Devin R. Burrill and Qun Niu and Dezheng Huo and Walmy Elisabeth Sveen and Temidayo Ogundiran and Clemet Adebamowo and Abayomi Odetunde and Adeyinka Gladys Falusi and Olufunmilayo I. Olopade},
  journal={International journal of cancer},
  year={2012},
  volume={131 5},
  pages={1114-23}
}
Inherited mutations in the BRCA1 and BRCA2 genes are the strongest genetic predictors of breast cancer and are the primary causes of familial breast/ovarian cancer syndrome. The frequency, spectrum and penetrance of mutant BRCA1/BRCA2 alleles have been determined for several populations, but little information is available for populations of African ancestry, who suffer a disproportionate burden of early onset breast cancer. We have performed complete sequence analysis of all BRCA1 and BRCA2… CONTINUE READING
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