High-pressure protein crystallography and NMR to explore protein conformations.

  title={High-pressure protein crystallography and NMR to explore protein conformations.},
  author={Marcus D. Collins and Chae Un Kim and Sol M Gruner},
  journal={Annual review of biophysics},
High-pressure methods for solving protein structures by X-ray crystallography and NMR are maturing. These techniques are beginning to impact our understanding of thermodynamic and structural features that define not only the protein's native conformation, but also the higher free energy conformations. The ability of high-pressure methods to visualize these mostly unexplored conformations provides new insight into protein function and dynamics. In this review, we begin with a historical… CONTINUE READING
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