High-pressure macromolecular crystallography and NMR: status, achievements and prospects.


Biomacromolecules are thermodynamic entities that exist in general as an equilibrium mixture of the basic folded state and various higher-energy substates including all functionally relevant ones. Under physiological conditions, however, the higher-energy substates are usually undetectable on spectroscopy, as their equilibrium populations are extremely low… (More)
DOI: 10.1016/j.sbi.2012.07.007


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