High-pressure liquid chromatographic determination of corticosteroids in topical pharmaceuticals.

@article{Williams1981HighpressureLC,
  title={High-pressure liquid chromatographic determination of corticosteroids in topical pharmaceuticals.},
  author={Peter Anthony Williams and E R Biehl},
  journal={Journal of pharmaceutical sciences},
  year={1981},
  volume={70 5},
  pages={530-4}
}
Cortisone, hydrocortisone, prednisolone, and prednisone were separated on a reversed-phase microparticulate high-pressure liquid chromatographic (HPLC) column with a ternary mobile solvent containing tetrahydrofuran, methanol, and water. Cortisone acetate, hydrocortisone acetate, and prednisolone acetate were separated on the same reversed-phase column using acetonitrile-water. Various commercial topical formulations of these corticosteroids, except cortisone and prednisone, were prepared by… CONTINUE READING