High pressure liquid chromatographic analysis and preliminary pharmacokinetics of sulfaphenazole and its N2-glucuronide and N4-acetyl metabolites in plasma and urine of man

@article{Vree2005HighPL,
  title={High pressure liquid chromatographic analysis and preliminary pharmacokinetics of sulfaphenazole and its N2-glucuronide and N4-acetyl metabolites in plasma and urine of man},
  author={T. Vree and E. W. B. Beneken Kolmer and Y. Hekster},
  journal={Pharmaceutisch Weekblad},
  year={2005},
  volume={12},
  pages={243-246}
}
  • T. Vree, E. W. B. Beneken Kolmer, Y. Hekster
  • Published 2005
  • Medicine
  • Pharmaceutisch Weekblad
  • A direct high pressure liquid chromatographic analysis of sulfaphenazole-N2-glucuronide in urine is described. After an oral dose of 439 mg of sulfaphenazole, 0% is excreted unchanged in the urine, < 1% is excreted as N4-acetylsulfaphenazole. As N2-glucuronide 49.4% is excreted in one slow acetylator and 84.8% in one fast acetylator. 
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