High-pressure gas phase femtosecond laser ionization mass spectrometry.

@article{Peng2012HighpressureGP,
  title={High-pressure gas phase femtosecond laser ionization mass spectrometry.},
  author={Jiahui Peng and Noah Puskas and P. B. Corkum and David Michael Rayner and Alexandre V. Loboda},
  journal={Analytical chemistry},
  year={2012},
  volume={84 13},
  pages={
          5633-40
        }
}
We describe a novel ion source for analytical mass spectrometry based on femtosecond laser ionization at pressures at and above atmospheric and characterize its performance when coupled to a tandem quadrupole/time-of-flight mass spectrometer. We assess source saturation limits, ionization and sampling efficiencies, the effective ionization volume, and limits of detection. We demonstrate 100% efficient ionization for a set of organic compounds and show that the degree of ion fragmentation over a… 

Figures from this paper

Gas chromatography/multiphoton ionization/time-of-flight mass spectrometry using a femtosecond laser

  • T. Imasaka
  • Chemistry, Physics
    Analytical and Bioanalytical Chemistry
  • 2013
TLDR
This technique of multiphoton ionization (MPI), when combined with time-of-flight mass spectrometry (TOF-MS), permits the efficient detection of induced ions in mass analysis and has proven itself to be a useful and practical method for trace analysis.

Super-atmospheric pressure ionization mass spectrometry and its application to ultrafast online protein digestion analysis.

TLDR
It is demonstrated that it is possible to achieve an online Asp-specific protein digestion analysis in which the whole processes of digestion, ionization and MS acquisition could be completed on the order of a few seconds, and the reaction can even be monitored on a near-real-time basis.

Detection limits of organic compounds achievable with intense, short-pulse lasers.

TLDR
The laser pulse parameters required for real-time detection of aromatic molecules at concentrations of one part per trillion in air and a limit of detection of a few attomoles are achievable with presently available commercial laser systems.

Super-atmospheric pressure chemical ionization mass spectrometry.

TLDR
For benzene, it was found that besides molecular ion and protonated species, ion due to [M + 2H](+) which was not so common in APCI, was also observed with high ion abundance under super-atmospheric pressure condition.

Super-atmospheric pressure ionization mass spectrometry and its application to ultrafast online protein digestion analysis.

TLDR
This Special Feature article, Lee Chuin Chen and colleagues review super-atmospheric pressure ionization MS with electrospray, corona-discharge-based chemical ionization, and field desorption with a new HP-ESI source.

Super-Atmospheric Pressure Ion Sources: Application and Coupling to API Mass Spectrometer.

TLDR
For nanoESI, which is known to work well with aqueous solution, its stability and sensitivity were found to be enhanced, particularly in the negative mode when the ion source was pressurized.

When API Mass Spectrometry Meets Super Atmospheric Pressure Ion Sources.

  • L. Chen
  • Physics
    Mass spectrometry
  • 2015
TLDR
Electrospray and the corona-based chemical ion source in most commercial instrument are basically operated under an atmospheric pressure ambient, perhaps out of the concern of safety, convenience and simplicity in maintenance.

Ion sources for mass spectrometric identification and imaging of molecular species.

TLDR
This broad overview groups ion sources into the following categories: electron ionization and single photon ionization; chemical ionization-like and plasma-based; electrospray ionized; and, laser desorption-based.

Fragmentation of Neutral Amino Acids and Small Peptides by Intense, Femtosecond Laser Pulses

TLDR
Fragment was dominated by fast, radical-initiated dissociation close to the charge site generated by the initial ionization or from subsequent ultrafast migration of this charge, and was attributed to radical migration caused by hydrogen atom transfer within the molecule.

Photodissociation Dynamics of 2-Iodotoluene Investigated by Femtosecond Time-Resolved Mass Spectrometry†

The photodissociation dynamics of 2-iodotoluene following excitation at 266 nm have been investigated employing femtosecond time-resolved mass spectrometry. The photofragments are detected by

References

SHOWING 1-10 OF 17 REFERENCES

Mass Spectrometry Sampling Under Ambient Conditions with Desorption Electrospray Ionization

TLDR
The DESI phenomenon was observed both in the case of conductive and insulator surfaces and for compounds ranging from nonpolar small molecules such as lycopene, the alkaloid coniceine, and small drugs, through polar compounds such as peptides and proteins.

An introduction to quadrupole-time-of-flight mass spectrometry.

TLDR
A brief introduction to the basic principles and application of a quadrupole-time-of-flight (TOF) tandem mass spectrometer and basic algorithms for liquid chromatography/MS/MS automation are discussed and illustrated by two applications.

Nonlinear ionization of organic molecules in high intensity laser fields

We use a series of 23 organic molecules to study ionization of complex media caused by their interaction with intense 40 fs, 0.8 &mgr;m pulses. All molecules reach saturated ionization at higher

Coulomb effect in multiphoton ionization of rare-gas atoms

Using 200 fs, 800 nm Ti:sapphire laser pulses to ionize noble atom gases, the ion versus intensity curves of these gases were obtained. By comparing the experimental curves with those obtained using

Electrospray and MALDI Mass Spectrometry: Fundamentals, Instrumentation, Practicalities, and Biological Applications

Foreword: Desorption Ionization and Spray Ionization: Connections and Progress ( R. Graham Cooks). Foreword to the First Edition (John B. Fenn). Preface (Richard B. Cole). Contributors. Part I

Intense-field laser ionization rates in atoms and molecules

Vous avez des questions? Nous pouvons vous aider. Pour communiquer directement avec un auteur, consultez la première page de la revue dans laquelle son article a été publié afin de trouver ses

Phys. Rev. Lett

  • Phys. Rev. Lett
  • 2000