High pneumococcal DNA loads are associated with mortality in Malawian children with invasive pneumococcal disease.

@article{Carrol2007HighPD,
  title={High pneumococcal DNA loads are associated with mortality in Malawian children with invasive pneumococcal disease.},
  author={Enitan D Carrol and Malcolm Guiver and Standwell C Nkhoma and Limangeni A. Mankhambo and John Marsh and Paul Balmer and Daniel Lawadi Banda and Graham Jeffers and Sarah Anne. White and Elizabeth Molyneux and Malcolm Edward Molyneux and R L Smyth and Charles A. Hart},
  journal={The Pediatric infectious disease journal},
  year={2007},
  volume={26 5},
  pages={
          416-22
        }
}
BACKGROUND In bacteremia owing to Streptococcus pneumoniae, high bacterial counts at presentation have been shown to be predictive of the development of serious invasive disease. Using real-time PCR, we aimed to determine pneumococcal DNA loads in blood and CSF, and their relationship to cytokine concentrations, clinical presentation and outcome. METHODS Children with confirmed meningitis (n = 82) or pneumonia (n = 13) were prospectively recruited, and blood and CSF samples taken for… CONTINUE READING
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