High plasma thiocyanate levels modulate protein damage induced by myeloperoxidase and perturb measurement of 3-chlorotyrosine.

@article{Talib2012HighPT,
  title={High plasma thiocyanate levels modulate protein damage induced by myeloperoxidase and perturb measurement of 3-chlorotyrosine.},
  author={Jihan Talib and David I. Pattison and Jason A. Harmer and David S Celermajer and Michael J Davies},
  journal={Free radical biology & medicine},
  year={2012},
  volume={53 1},
  pages={20-9}
}
Smokers have an elevated risk of atherosclerosis but the origin of this elevated risk is incompletely defined, though increasing evidence supports a role for the oxidant-generating enzyme myeloperoxidase (MPO). In previous studies we have demonstrated that smokers have elevated levels of thiocyanate ions (SCN(-)), relative to nonsmokers, and increased thiol oxidation, as SCN(-) is a favored substrate for MPO, and the resulting hypothiocyanous acid (HOSCN) targets thiol groups rapidly and… CONTINUE READING

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Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention

Journal of clinical biochemistry and nutrition • 2011
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