High plasma thiocyanate levels in smokers are a key determinant of thiol oxidation induced by myeloperoxidase.

@article{Morgan2011HighPT,
  title={High plasma thiocyanate levels in smokers are a key determinant of thiol oxidation induced by myeloperoxidase.},
  author={Philip Edwin Morgan and David I. Pattison and Jihan Talib and Fiona A. Summers and Jason Anthony Harmer and David S Celermajer and Clare L Hawkins and Michael J Davies},
  journal={Free radical biology & medicine},
  year={2011},
  volume={51 9},
  pages={
          1815-22
        }
}
Smokers have an elevated risk of atherosclerosis but the origins of this elevated risk are incompletely defined, though evidence supports an accumulation of the oxidant-generating enzyme myeloperoxidase (MPO) in the inflamed artery wall. We hypothesized that smokers would have a high level of thiocyanate (SCN(-)), a preferred substrate for MPO, which in turn would predispose to thiol oxidation, an established independent risk factor for atherosclerosis. In this study it is shown that on… CONTINUE READING
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