High plasma proopiomelanocortin in aggressive adrenocorticotropin-secreting tumors.

@article{RaffinSanson1996HighPP,
  title={High plasma proopiomelanocortin in aggressive adrenocorticotropin-secreting tumors.},
  author={Marie Laure Raffin-Sanson and J F Massias and C. B. S. Dumont and Marie-Charles Raux-Demay and M F Proeschel and Jean Pierre Luton and Xavier Y Bertagna},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1996},
  volume={81 12},
  pages={4272-7}
}
A specific propiomelanocortin (POMC) immunoradiometric assay was developed using antibodies directed against ACTH and beta-endorphin (beta end). Partially purified standard POMC was prepared from the human small cell lung carcinoma cell line DMS-79 culture medium. Ten units (U) POMC had the same displacement ability as one pg beta end in a C-terminal beta end radioimmunoassay and thus were close if not equal to 10 pg POMC. This POMC assay was used to investigate patients with ACTH-dependent… CONTINUE READING

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