High plasma norepinephrine levels in patients with major affective disorder.

@article{Lake1982HighPN,
  title={High plasma norepinephrine levels in patients with major affective disorder.},
  author={C. Raymond Lake and David Pickar and Michael G. Ziegler and Steven Lipper and Stanley Slater and Dennis L. Murphy},
  journal={The American journal of psychiatry},
  year={1982},
  volume={139 10},
  pages={1315-8}
}
The authors found that patients with major affective disorder had higher levels of plasma norepinephrine and higher pulse rates (tachycardia) than healthy control subjects, but their blood pressures were normal. These measurements were similar in all three subgroups of patients with affective disorder--manic, bipolar depressed, and unipolar. Because norepinephrine is the primary neurotransmitter of the sympathetic nervous system, these data suggest sympathetic hyperactivity in the major… CONTINUE READING

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