High plasma levels of endothelin-1 enhance the predictive value of preclinical atherosclerosis for future cerebrovascular and cardiovascular events: a 20-year prospective study.

@article{Novo2014HighPL,
  title={High plasma levels of endothelin-1 enhance the predictive value of preclinical atherosclerosis for future cerebrovascular and cardiovascular events: a 20-year prospective study.},
  author={Giuseppina Novo and Angela Sansone and Manfredi Rizzo and Francesco Paolo Guarneri and Claudio Pernice and Salvatore Novo},
  journal={Journal of cardiovascular medicine},
  year={2014},
  volume={15 9},
  pages={
          696-701
        }
}
BACKGROUND AND PURPOSE Clinical and experimental evidence suggests that endothelin-1 (ET-1) plays a role in cardiac and vascular disease. In the present study, we investigated the prognostic significance of ET-1 for cerebrovascular and cardiovascular outcome, in a 20-year follow-up. METHODS We studied 82 originally healthy individuals, referred to our Unit of Cardiovascular Prevention, to evaluate the presence of asymptomatic carotid lesions. We subdivided these individuals into two groups… CONTINUE READING
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